It's a classic rivalry with just 34 miles separating each other up the M62, however it is not Liverpool's old foes in red that they face, it's Pep's Blues that the Reds will host tonight in the quarter-finals of the Champions League.
Both sets of fans would have wanted to avoid each other when the draw was originally made, with both sides easily dispatching the likes of FC Porto and FC Basel in the previous round, it is a game that is being billed as one of the biggest in Europe.
There is no secret in the amount of hype and momentum that this game has gathered over the past week, even before last weekend's Premier League games, both sets of supporters would have had their eye on this game, maybe more for the visitors as they have the chance to win the title against local rivals Manchester United this weekend coming.
Both sides will meet for the first time in European competition this evening, overall it will be their 179th competitive match. In their two meetings earlier on in the season, there has been 12 goals scored with 26% of the shots attempted scored.
This could mean either one of two things, that we are guaranteed a goal fest this evening or we are in the for the most boring 90 minutes of football ever to take place in a British stadium, there will be no in between.
Tactically, it could be interesting to see the way that Manchester City will set his side up when they arrive at Anfield after hinting to reporters during his press conference that he would not change his winning ways, don't fix what isn't broken, so to speak.
Liverpool are expected to go out all guns blazing from the off, as manager Jurgen Klopp has rallied Liverpool fans to be at their best when kick off comes around.
Both sides are carrying their fair share of injuries with Liverpool recently losing Joel Matip until the end of the season and Adam Lallana limping off against Crystal Palace after being brought on as a substitute. Emre Can is also a doubt as he is carrying a back injury. Milner expected to start alongside Oxlade-Chamberlain and skipper Jordan Henderson.
Manchester City will be without Sergio Aguero for the first leg, the Argentine has never scored at Anfield but the visitors will have plenty of fire power in reserve if needed as Gabriel Jesus is expected to start. John Stones is a doubt as he recovers from a concussion. Nicolas Otamendi is expected to partner Vincent Kompany at the hear of the City back line.
The game gets underway at 19:45 UK time and the game will be shown live on BT Sport 2 and BT Sport HD, for those who haven't been fortunate enough to get a ticket for tonight's all-British European affair.