Phenylhydrazine Hydrochloride is a white to tan solid with a weak odor. It is used in the manufacture of dyes and pharmaceuticals.
Phenyl-hydrazine is used to prepare indoles by the Fischer indole synthesis, which are intermediates in the synthesis of various dyes and pharmaceuticals. Phenylhydrazine is used to form phenylhydrazones of natural mixtures of simple sugars in order to render the differing sugars easily separable from each other.
NIOSH REL: 0.14 ppm (0.6 mg/m3) 2-hr CEILING [skin]; NIOSH considers phenylhydrazine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Hydroxyzine is used to treat itching caused by allergies. It is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Hydroxyzine may also be used short-term to treat anxiety or to help you feel sleepy/relaxed before and after surgery.
1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them. Phenylhydrazine is the chemical compound with the formula C6H5NHNH2. It is often abbreviated as PhNHNH2.
Osazone test is a chemical test used to detect reducing sugars. This test even allows the differentiation of different reducing sugars on the basis of the time of appearance of the complex. This test is also termed Phenyl hydrazine test based on the reagent used for this test.
Phenylhydrazine is soluble (in water) and a very strong basic compound (based on its pKa).
Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, droperidol, pimozide, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation and should not be used in combination with hydroxyzine.
Generally speaking, hydroxyzine is an antihistamine related to over-the-counter (OTC) medications like Benadryl and Zyrtec that are used to treat symptoms of allergies and colds such as runny nose and itchy or watery eyes.
Hydroxyzine and Xanax belong to different drug classes. Hydroxyzine is an antihistamine with anticholinergic (drying) and sedative properties and Xanax is an anti-anxiety medication in the benzodiazepine class. A brand name for hydroxyzine is Vistaril.
Phenylhydrazine and its derivatives were used as antipyretics, but studies have shown that these compounds have toxic effects on blood cells. However, use of this compound as a drug is limited. Nowadays, it is used as a chemical compound to induce anemia in animal studies.
It is soluble in water (values ranging from 145 to 837 g/litre at 24 °C have been reported) and is miscible with alcohol, ether, chloroform, benzene, and acetone. The conversion factor for phenylhydrazine is 1 ppm = 4.5 mg/m3 (at 20 °C, 101 kPa).
Phenylhydrazine is a pale yellow crystal or an oily liquid with a faint aromatic odor.
Dissolve 15 g PMA in 500 mL distilled water, allow to stand one day, and filter before use through a fluted paper filter. 7. Phenylhydrazine hydrochloride stock solution. Weigh accurately 0.1 g phenylhydrazine hydrochloride into a 100-mL volumetric flask and fill to the mark with 0.1 M HCl.
Glucose reacts with phenylhydrazine to give glucose phenylhydrazone which is soluble in water. If excess of phenylhydrazine is used, dihydrazone, known as glucosazone is formed.
Official Answer. Atarax was most likely discontinued in the US due to business reasons by its manufacturer. It was not removed from the market for safety or effectiveness reasons, according to the FDA. A generic version of Atarax known as hydroxyzine hydrochloride is available in the US and is very affordable.
Atarax (hydroxyzine) effectively relieves itching caused by an allergic reaction. It can also help alleviate anxiety, but isn't a first choice medicine and can make you very sleepy. Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
Does hydroxyzine cause weight gain? No, hydroxyzine isn't known to cause weight gain. This side effect wasn't reported by people taking the drug in clinical studies. If you're concerned about changes in your weight while taking hydroxyzine, talk with your doctor.
Hydroxyzine is not a controlled substance. It does not have the risk of addiction like some other medications used to treat anxiety e.g., lorazepam (Ativan®), alprazolam (Xanax®), clonazepam (Klonopin®), and other benzodiazepines.
The synthesis of phenylhydrazine involving the diazotization of aniline, the reduction of the resulting diazonium salt with an excess amount of sodium sulfite, and the hydrolysis of phenylhydrazine sulfonic acid salt with hydrochloric acid is known as Fischer phenylhydrazine synthesis.
The condensation between phenylhydrazine and a carbonyl compound (aldehyde or ketone) to form phenylhydrazone and the compounds condensed from carbohydrates and 2 eq of phenylhydrazine are generally known as osazones or specifically referred to as glycosazones.